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Leptomeningeal Carcinomatosis:Presenting Features and Prognostic Factors Arch Neurol 53:626-632, Balm,M.&Hammack,J., 1996 See this aricle in Pubmed Article Abstract Independent negative predictors of survival include elevated CSF protein and clinical involvement of the cerebral leptomeninges.Independent positive predictors of survival were longer duration of neurological symptoms at the time of presentation,treatment with intrathecal or intraventricular(intra-CSF)chemotherapy and female sex.Other variables including age,primary tumor type and extent of systemic disease,were not predictive.We conclude that female sex,longer duration of neurological symptoms,absence of cerebral leptomeningeal clinical involvement and absence of elevated CSF protein independently predict better survival. Patients treated with intra-CSF chemotherapy also survived longer.

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